Publications

Dive into our discoveries and see how the brain takes action!

key publications patents locomotion basal ganglia Parkinson's disease respiration spinal cord injury

2026

A Uniform Tissue-Clearing Framework and MesoSPIM-Ultra Enable Cm-Scale Single-Neuron Tracing
A Uniform Tissue-Clearing Framework and MesoSPIM-Ultra Enable Cm-Scale Single-Neuron Tracing
Pende M*,†, Cregg JM*, Saghafi S, Broadbent S, Avdibasic A, Roeles J, Papadopoulos SC, Seaman RP, Pende N, Mateos MS, Jamwal K, Wunch M, Pasierbek P, Moreno-Cencerrado A, Korchynska S, Hauer R, Anderson P, Supper P, Kastriti ME, Reumann D, Moorhead M, Graber JHH, Scholze P, Henschke JU, Budinger E, Knoblich JA, Klausberger T, Adameyko I, Harkany T, Kumar V, Joy MT, Kiehn O, Dodt HU†, Voigt F†, Prayag Murawala†,#
bioRxiv   ·   04 Jul 2026   ·   *Co-first authors. †Co-corresponding authors. # Lead contact.
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2024

Basal Ganglia-Spinal Cord Pathway that Commands Locomotor Gait Asymmetries in Mice
Basal Ganglia-Spinal Cord Pathway that Commands Locomotor Gait Asymmetries in Mice
Cregg JM†, Sidhu SK, Leiras R, Kiehn O†
Nature Neuroscience   ·   12 Feb 2024   ·   †Co-corresponding authors.
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2023

Highlights from the 31st Annual Meeting of the Society for the Neural Control of Movement
Highlights from the 31st Annual Meeting of the Society for the Neural Control of Movement
Cregg JM†, Mirdamadi JL, Fortunato C, Okorokova EV, Kuper C, Nayeem R, Byun AJ, Avraham C, Buonocore A, Winner TS, Mildren RL
Journal of Neurophysiology   ·   01 Jan 2023   ·   †Corresponding author.
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2022

Brainstem Circuits for Locomotion
Brainstem Circuits for Locomotion
Leiras R*, Cregg JM*, Kiehn O
Annual Review of Neuroscience   ·   08 Jul 2022   ·   *Co-first authors.
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2020

Brainstem Neurons that Command Mammalian Locomotor Asymmetries
Brainstem Neurons that Command Mammalian Locomotor Asymmetries
Cregg JM, Leiras R, Montalant A, Wanken P, Wickersham IR, Kiehn O
Nature Neuroscience   ·   11 May 2020
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Phrenic-Specific Transcriptional Programs Shape Respiratory Motor Output
Phrenic-Specific Transcriptional Programs Shape Respiratory Motor Output
Vagnozzi AN, Garg K, Dewitz C, Moore MT, Cregg JM, Jeannotte L, Zampieri N, Landmesser LT, Philippidou P
eLife   ·   16 Jan 2020
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2019

Three-Dimensional Scaffolds, Methods for Fabricating the Same, and Methods of Treating a Peripheral Nerve or Spinal Cord Injury
Three-Dimensional Scaffolds, Methods for Fabricating the Same, and Methods of Treating a Peripheral Nerve or Spinal Cord Injury
Hurtado A, Gilbert RJ, Wang HB, Cregg JM, Mullins ME, Oudega M
US Patent   ·   17 Sep 2019
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Brainstem Neurons that Command Left/Right Locomotor Asymmetries
Brainstem Neurons that Command Left/Right Locomotor Asymmetries
Cregg JM, Leiras R, Montalant A, Wickersham IR, Kiehn O
bioRxiv   ·   03 Sep 2019
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Compositions and Methods of Treating Root Avulsion Injury
Compositions and Methods of Treating Root Avulsion Injury
Silver J, Lang BT, Cregg JM, Weng YL, Li H, Wu W
US Patent   ·   16 Apr 2019
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2018

Rapid Functional Genetics of the Oligodendrocyte Lineage using Pluripotent Stem Cells
Rapid Functional Genetics of the Oligodendrocyte Lineage using Pluripotent Stem Cells
Lager AM, Corradin OG, Cregg JM, Elitt MS, Shick HE, Clayton BLL, Allan KC, Olsen HE, Madhavan M, Tesar PJ
Nature Communications   ·   13 Sep 2018
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Compositions and Methods for Inhibiting the Activity of LAR Family Phosphatases
Compositions and Methods for Inhibiting the Activity of LAR Family Phosphatases
Lang BT, Cregg JM, Silver J, Weng YL
US Patent   ·   10 Apr 2018
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2017

Phasic Inhibition as a Mechanism for Generation of Rapid Respiratory Rhythms
Phasic Inhibition as a Mechanism for Generation of Rapid Respiratory Rhythms
Cregg JM, Chu KA, Dick TE, Landmesser LT†, Silver J†
Proceedings of the National Academy of Sciences USA   ·   13 Nov 2017   ·   †Co-corresponding authors.
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A Latent Propriospinal Network Can Restore Diaphragm Function after High Cervical Spinal Cord Injury
A Latent Propriospinal Network Can Restore Diaphragm Function after High Cervical Spinal Cord Injury
Cregg JM, Chu KA, Hager LE, Maggard RSJ, Stoltz DR, Edmond M, Alilain WJ, Philippidou P, Landmesser LT, Silver J
Cell Reports   ·   01 Oct 2017
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2016

Overexpression of the Monocyte Chemokine CCL2 in Dorsal Root Ganglion Neurons Causes a Conditioning-Like Increase in Neurite Outgrowth and does so via a STAT3 Dependent Mechanism
Overexpression of the Monocyte Chemokine CCL2 in Dorsal Root Ganglion Neurons Causes a Conditioning-Like Increase in Neurite Outgrowth and does so via a STAT3 Dependent Mechanism
Niemi JP, DeFrancesco-Lisowitz A, Cregg JM, Howarth M, Zigmond RE
Experimental Neurology   ·   01 Jan 2016
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2015

Targeting Protein Tyrosine Phosphatase σ after Myocardial Infarction Restores Cardiac Sympathetic Innervation and Prevents Arrhythmias
Targeting Protein Tyrosine Phosphatase σ after Myocardial Infarction Restores Cardiac Sympathetic Innervation and Prevents Arrhythmias
Gardner RT, Wang L, Lang BT, Cregg JM, Dunbar CL, Woodward WR, Silver J, Ripplinger CM, Habecker BA
Nature Communications   ·   02 Feb 2015
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2014

Modulation of the Proteoglycan Receptor PTPσ Promotes Recovery after Spinal Cord Injury
Modulation of the Proteoglycan Receptor PTPσ Promotes Recovery after Spinal Cord Injury
Lang BT, Cregg JM, DePaul MA, Tran AP, Xu K, Dyck SM, Madalena KM, Brown BP, Weng YL, Li S, Karimi-Abdolrezaee S, Busch SA, Shen Y, Silver J
Nature   ·   03 Dec 2014
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Functional Regeneration Beyond the Glial Scar
Functional Regeneration Beyond the Glial Scar
Cregg JM, DePaul MA, Filous AR, Lang BT, Tran A, Silver J
Experimental Neurology   ·   01 Mar 2014
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2012

Keratan Sulfate Proteoglycans in Plasticity and Recovery after Spinal Cord Injury
Keratan Sulfate Proteoglycans in Plasticity and Recovery after Spinal Cord Injury
Hilton BJ, Lang BT, Cregg JM
Journal of Neuroscience   ·   28 Mar 2012
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2011

Robust CNS Regeneration After Complete Spinal Cord Transection using Aligned Poly-L-Lactic Acid Microfibers
Robust CNS Regeneration After Complete Spinal Cord Transection using Aligned Poly-L-Lactic Acid Microfibers
Hurtado A*, Cregg JM*, Wang HB, Wendell DF, Oudega M, Gilbert RJ, McDonald JW
Biomaterials   ·   01 Sep 2011   ·   *Co-first authors.
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2010

Varying the Diameter of Aligned Electrospun Fibers Alters Neurite Outgrowth and Schwann Cell Migration
Varying the Diameter of Aligned Electrospun Fibers Alters Neurite Outgrowth and Schwann Cell Migration
Wang HB, Mullins ME, Cregg JM, McCarthy CW, Gilbert RJ
Acta Biomaterialia   ·   01 Aug 2010
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2009

A Rapid, Quantitative Method for Assessing Axonal Extension on Biomaterial Platforms
A Rapid, Quantitative Method for Assessing Axonal Extension on Biomaterial Platforms
Cregg JM, Wiseman SL, Pietrzak-Goetze NM, Smith MR, Jaroch DB, Clupper DC, Gilbert RJ
Tissue Engineering Part C: Methods   ·   01 Apr 2009
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2008

Creation of Highly Aligned Electrospun Poly-L-Lactic Acid Fibers for Nerve Regeneration Applications
Creation of Highly Aligned Electrospun Poly-L-Lactic Acid Fibers for Nerve Regeneration Applications
Wang HB, Mullins ME, Cregg JM, Hurtado A, Oudega M, Trombley MT, Gilbert RJ
Journal of Neural Engineering   ·   28 Dec 2008
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